Clinician Research Portal

Frequently Reviewed Studies

Efficacy of a Novel Skin Antiseptic Against Carbapenem-resistant Enterobacteriaceae Timothy L. Wiemken, Robert R. Kelley, Ruth M. Carrico, Laura E. Binford, Brian E. Guinn, William A. Mattingly, and others American Journal of Infection Control Vol. 43 Issue 4 p380-382 February 5, 20150.1
Efficacy and safety of a novel skin cleansing formulation versus chlorhexidine gluconate.  Paulson DS, Topp R, Boykin RE, Schultz G, Yang Q.  American Journal of Infection Control, Vol 46, Issue 11, p1262-1265, June 5, 2018H2H.3
Evaluating the effectiveness of a multidimensional bundle to reduce urinary tract infection in long-term care spinal cord injury/disordered patients: a retroactive review.  Edward Hines Jr VA Hostpital. Chaiken N, Pazzaglia J, Polakkattil B, Tower-Woods W, Schwartz R, Lombardo  R. Journal of Wound Ostomy & Continence Nursing, May 2020CAUTI.11
Beyond the Bundles: A Pilot to Evaluate a Silver Based Bathing Product to Reduce Central Line-Associated Bloodstream Infections.  Lisa Pinner, RN, MSN, CNS, CPON, BMTCN, Rachel Frisch, BSN, BMTCN, Jenna Kruger, MPH, CPHQ, and Lianna Marks, MD. Lucile Packard Children’s Hospital (Stanford Health)CLABSI.46
Zero CAUTI, zero CLABSI: evaluating the evidence-based effectiveness of a silver, pH acidic, multimodal skin decolonizing wipe to reduce catheter associated urinary tract infection and central line blood stream infections in the ICU setting: a retrospective review.  Tenet Health – Doctors Medical Center of Modesto, 2020Asif Sayed A., MBA, CIC, Director of Infection Prevention CAUTI/CLABSI.12
CLABSI Reduction Seen with Multifactorial Nurse Initiative  John Muir Health, CA. Poster submittal ANCC Magnet Association, Fall Session, 2017CLABSI.18

Institutional Clinical Studies by Event & Location

CAUTI/UTI: (Catheter Acquired Urinary Tract Infection): Institutional Studies

Zero CAUTI, zero CLABSI: evaluating the evidence-based effectiveness of a silver, pH acidic, multimodal skin decolonizing wipe to reduce catheter associated urinary tract infection and central line blood stream infections in the ICU setting: a retrospective review. Health – Doctors Medical Center of Modesto, 2020Asif Saiyed, MBA, CIC, Director of Infection Prevention CAUTI/CLABSI.12
Evaluating the effectiveness of a multidimensional bundle to reduce urinary tract infection in long-term care spinal cord injury/disordered patients: a retroactive review. Edward Hines Jr VA Hospital. Chaiken N, Pazzaglia J, Polakkattil B, Tower-Woods W, Schwartz R, Lombardo R. Journal of Wound Ostomy & Continence Nursing, May 2020 CAUTI.11
One Year CAUTI Free A Multi- Disciplinary Team approach to Reducing CAUTI in Pediatric Intensive Care Unit Spectrum Health Helen Devos Children’s Hospital CAUTI.47
The Theraworx Silver First Protocol: Impact on CAUTIs. Cleveland Clinic CAUTI.48
Targeting Zero: One Hospital’s Journey to Reduce CAUTI Roser L, Piercy EC, Altpeter, T. Journ. Of Nurs Mgt 18-20 Dec 2014 CAUTI.24
Effects of Education and Improved Foley Catheter Care on Nurse’s Knowledge and CAUTI First Health of the Carolinas,Walters G, Lee J, Riddle L Poster presentation CAUTI.20
Theraworx Skin Care Formulation Reduces Nosocomial Associated CAUTI Rates When Used For Urinary Catheter Insertion and Maintenance. Renzulli, J Journal of Clinical and Medical Investigation. Vol 2(2): 1-3 CAUTI.15
Innovative “Eco-Friendly” skin care formulation reduces nosocomial associated CAUTI rates when used for insertion and maintenance of urinary catheters. George A Turini III M.D, MSc., Joseph F. Renzulli II M.D., Department of Urology – Section of Minimally Invasive Urologic Surgery CAUTI.14
Preventing Chronic Urinary Tract Infections From Urine and Fecal Incontinence: The Impact of Theraworx Peterson Healthcare, Peoria IL, Poster presentation UTI.21
Closing the gap: targeting CAUTIs with a novel approach to perineal care. Hargett L, Anderson T. Journal of Critical Care Nursing, April 2020 – University of Maryland Medical System UTI.21
Strategies to Prevent Urinary Tract Infection from Urinary Catheter Insertion in the Emergency Department Journal of Emerg Nursing, 36(6) November 2010 CAUTI.17
Can’t Attribute UTI TO Insertion: Utilizing Data to Prevent CAUTI – UW Medicine University of Washington Medical Center CAUTI.49
m. Equipping Clinicians with Advanced Care Options Leads to Reduction in UTI: Theraworx Works Wonders. Meadowview Health and Rehab Center, AHCA Spring Session, 2017 Poster presentation UTI.23

CLABSI (Central Line Blood Stream Infection): Institutional Studies

CLABSI Reduction Seen with Multifactorial Nurse Initiative John Muir Health, CA. Poster submittal, ANCC Magnet Association, Fall Session, 2017 CLABSI.18
Zero CAUTI, zero CLABSI: evaluating the evidence-based effectiveness of a silver, pH acidic, multimodal skin decolonizing wipe to reduce catheter associated urinary tract infection and central line blood stream infections in the ICU setting: a retrospective review. Asif Saiyed, MBA, CIC, Director of Infection Prevention Tenet Health – Doctors Medical Center of Modesto, 2020 CAUTI/CLABSI.12
Beyond the Bundles: A Pilot to Evaluate a Silver Based Bathing Product to Reduce Central Line-Associated Bloodstream Infections. Lisa Pinner, RN, MSN, CNS, CPON, BMTCN, Rachel Frisch, BSN, BMTCN, Jenna Kruger, MPH, CPHQ, and Lianna Marks, MD. Lucile Packard Children’s Hospital (Stanford Health) CLABSI.46
Journal of Critical Care Nursing: Change has arrived: antimicrobial bathing and CLABSI. Sung P, Virgallito M, Murphy T, Boghossian R, Young R. Journal of Critical Care Nursing, April 2020 USC Verdugo Hills HospitalCLABSI.9
Journal of Pediatric Oncology Nursing: Effectiveness of bath wipes after hematopoietic cell transplantation: a randomized trial. St Jude Children’s Hospital. Margie K, Qudeimat A, Browne E, Keerthi D, Sunkara A, Kang G, et al. Journal of Pediatric Oncology Nursing, 2020CLABSI.8

Clostridium Difficile (CDI): Institutional Studies

Preventing hospital acquired clostridium difficile infection in ICU patients: the efficacy of Theraworx, a novel silver-based cleanser. Northwell Health – Peconic Bay Medical Center T. Dhansew DO, M. Masih MD, P. Paunikar MD, MPH, P. Mupo RN, BSN, H. Fischer RN, BSN Academic Competition and Research Symposium, 06/2020 CDI.13
Reducing the Incidence of Clostridium Difficile Infections, Antibiotics and Costs in a Long-Term Care Setting – A Surveillance Experience. Levindale Lifebridge Health Center. Susan M Johnston, BSN, CIC CDI.50

Children’s Hospitals Studies

Beyond the Bundles: A Pilot to Evaluate a Silver Based Bathing Product to Reduce Central Line-Associated Bloodstream Infections. Lucile Packard Children’s Hospital (Stanford Health) Lisa Pinner, RN, MSN, CNS, CPON, BMTCN, Rachel Frisch, BSN, BMTCN, Jenna Kruger, MPH, CPHQ, and Lianna Marks, MD. CLABSI.46
One Year CAUTI Free A Multi-Disciplinary Team approach to Reducing CAUTI in Pediatric Intensive Care Unit Helen Devos Children’s hospital, Grand Rapids, MichiganJessica McClusky, MSN, RN, CPN, CIC CAUTI.47
Effectiveness of bath wipes after hematopoietic cell transplantation: a randomized trial St Jude Children Hospital. Margie K, Qudeimat A, Browne E, Keerthi D, Sunkara A, Kang G, et al. Journal of Pediatric Oncology Nursing, 2020 CLABSI.8

Alternate Site Studies

Preventing Chronic Urinary Tract Infections From Urine and Fecal Incontinence: The Impact of Theraworx Peterson Healthcare, Peoria IL Poster presentation UTI.22
Equipping Clinicians with Advanced Care Options Leads to Reduction in UTI: Theraworx Works Wonders. Meadowview Health and Rehab Center, Poster presentation, AHCA Spring Session, 2017 UTI.23
Evaluating the effectiveness of a multidimensional bundle to reduce urinary tract infection in long-term care spinal cord injury/disordered patients: a retroactive review.
Edward Hines Jr VA Hospital Chaiken N, Pazzaglia J, Polakkattil B, Tower-Woods W, Schwartz R, Lombardo R. Journal of Wound Ostomy & Continence Nursing, May 2020 CAUTI.11
Successful healing of IAD when traditional barriers fail using an innovative topical formulation. Diana Gallagher MS, RN, CWOCN, CFCN, Janalynn Miller FNP-C, GNP, CWCN-AP Symposium for Advanced Wound Care Fall 2018. Poster Presentation
Historical comparison of soft-tissue infections in a Division 1 wrestling team after adoption of a novel pH barrier product. Duke University Shaheen S, Bytomski J, Demyonovich D. The Journal of Sports Medicine and Physical Fitness, May 2018 AS.16
Topical innovation used in the treatment of more than 4-million ICU patients in the prevention of hospital acquired infections now proven to reduce the incidence of infections during special operations training. Camp MacKall Renzulli J, Pollock G, Strayer S, Lombardo R. Journal of Military Medicine, September 2020. AS.26

Organisms, Wound & Skin

Organism Efficacy Studies

Microbial Test Results: Microbial Testing Executive Summary Microbiological Consultants, Apptec Laboratories, St. John’s Research Institute O.40
Efficacy of a novel skin antiseptic against carbapenem-resistant EnterobacteriaceaeAmerican Journ of Infection Control, Vol. 43 Issue 4 p380–382. Published Online February 5, 2015 LINK Timothy L. Wiemken, Robert R. Kelley, Ruth M. Carrico, Laura E. Binford, Brian E. Guinn, William A. Mattingly, and others O.1
Efficacy and safety of a novel skin cleansing formulation versus chlorhexidine gluconate Major American Journal of Infection Control, Vol. 46 Issue 11 p.1262–1265 Published online: June 5, 2018Paulson DS, Topp R, Boykin RE, Schultz G, Yang Q. H2H.3
An Evaluation of One Test Product For It’s Antimicrobial Properties When Challenged with Three Microorganisms Using an Invitro Time-Kill Candida Auris testing Bioscience Laboratories, Inc. unpublished, prepared for publication O.36
Duration of Action of Theraworx Against Methicillin-resistant Staphylococcus Aureus Utilizing an Innoculated Collagen Model. St. John’s Medical Research Institute Huckfeldt R, Controlled comparative study O.7
Antimicrobial effectiveness of rinse-free hospital bathing cleansers after 24 h of initial exposure to common pathogenic micro-organisms. Olivi J, Austin CL, Thompson SJ. Journal of Patient Care, 2018 O.4
Theraworx V. Chlorhexidine Gluconate Bathing and Peri-Operative Skin Cleansing Study. St. John’s Research Center, St. John’s Research Center, Huckfeldt R, et al Controlled comparative study H2H.6
Another tool in the toolbox: a novel, multimodal, surfactant-based skin cleanser vs. 62% ethanol on the human coronavirus OC43 on human tissue. Paulson DS. Journal of Clinical and Medical Investigations, October 2020 O.1
Activity of a novel, multimodal, surfactant-based skin cleanser on coronaviruses, in-vitro. Paulson DS. Journal of Clinical and Medical Investigations, September 2020 O.2
Ex-Vivo Antibacterial Evaluation of Topical Products Using a Vitro-Skin Model. ATS LABS O.37
Evaluation of One Test Article for Virucidal Properties Based Upon the ASTM E1052-20 Method Nelson Labs O.4
Evaluation of One Test Article for Virucidal Properties when Challenged with Respiratory Syncytial Virus (RSV) Nelson Labs O.5

Wound and Skin Integrity Studies

Symposium on Advanced Wound Care SAWC: Effect of an innovative pH lowering wound therapeutic on MMP levels and bacterial biofilm colonization of chronic non-healing wounds. Marston W, Schultz G. Poster presentation, Symposium on Advanced Wound Care, Fall 2018. WC.27
Effect of an innovative pH lowering wound therapeutic on MMP levels and bacterial biofilm colonization of chronic non-healing wounds. William Marston, Gregory Schultz, Zachary Gortler, Kurt Schultz, Soo Jung Seo, Daniel Gibson, Haley Engelken Poster presentation, Symposium on Advanced Wound Care, Fall 2019. WC.31
Harnessing the microbiome to rapidly resolve peristomal skin complications. Gallagher D, Juergens J. Poster presentation, Symposium on Advanced Wound Care, Spring 2019. WC.28
Successful healing of IAD when traditional barriers fail using an innovative topical formulation. Gallagher D, Miller J. Poster presentation, Symposium on Advanced Wound Care, Fall 2018 WC.29
Non-toxic skin formulation promotes healing of dermatitis and skin injuries that are prone to infection in long-term care facility residents. Miller J, Renzulli J. F. Annals of Infectious Disease and Epidemiology, November 2016 WC.30
Novel Skin Care System Helps in Healing Skin Wounds and Other Problematic Skin Disorders in Patients at Long-term Care facilities. Janalynn Miller FNP-C, GNP, CWCN-AP W.O.W. Case series (Wild on Wounds) National Conf Fall session 2016 WC.32

Clinical Data Brochure

Clinical Data Brochure, Avadim Health (Long Version)Clinical Data Brochure, Avadim Health (Short Version) CDB.1

Reference Documents

The Skin Barrier as an Innate Immune Element Elias PM. Semin Immunopath (2007) 29:3-14 R.1
Endorsement Letter and information on testing results, Dr. Peter Elias, UCSF R.2
The How, Why, and Clinical Importance of Stratum Corneum Acidification Elias, PE Experimental Dermatology Journ March 2017 R.3
pH Directly Regulates Permeability Barrier Homeostasis and Stratum Corneum Cohesion/Integrity Hachem JP, et.al., Journ Invest Dematol, August 2003, issue: 121(12), p: 345-53 R.4
Shea Antimicrobial-resistant pathogens associated with ADULT HAI: Summary of data reported to the NHSN. 2015-2017 R.5
Shea Antimicrobial-resistant pathogens associated with Pediatric HAI: Summary of data reported to the NHSN. 2015-2017 R.6
HAI Summary of Data Reported to NHSN. 2011-2014 R.7

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